Description for KRAS
DNA KRAS
Species Homo sapiens
 KRAS identified in exosomes derived from the following tissue/cell type
Plasma [Extracellular Vesicles] 33915956   
Plasma [Extracellular Vesicles] 36591510   
Plasma [Nanoscale extracellular Vesicles] 31232418   
Plasma [Extracellular Vesicles] 31596073   
Plasma [Extracellular Vesicles] 33915956   
Pleural effusion [Exosomes] 31555514   
Serum [Exosomes] 24398677   
 Experiment description of studies that identified KRAS in exosomes
1
Experiment ID3576
Identified moleculedsDNA-mutated
Identification methodWhole exosome sequencing
PubMed ID 33915956   
OrganismHomo sapiens
Experiment descriptionExosomes from Plasma of Neuroblastoma Patients Contain Doublestranded DNA Reflecting the Mutational Status of Parental Tumor Cells
AuthorsDegli Esposti C, Iadarola B, Maestri S, Beltrami C, Lavezzari D, Morini M, De Marco P, Erminio G, Garaventa A, Zara F, Delledonne M, Ognibene M, Pezzolo A.
Journal name Int J Mol Sci
Publication year2021
SamplePlasma
Sample nameNeuroblastoma
Molecules identified in the studydsDNA-mutated
Methods used in the studyWhole exosome sequencing
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2
Experiment ID3556
Identified moleculedsDNA
Identification methodddPCR
PubMed ID 36591510   
OrganismHomo sapiens
Experiment descriptionDetection of circulating KRAS mutant DNA in extracellular vesicles using droplet digital PCR in patients with colon cancer
AuthorsChoi J, Cho HY, Jeon J, Kim KA, Han YD, Ahn JB, Wortzel I, Lyden D, Kim HS.
Journal name Front Oncol
Publication year2022
SamplePlasma
Sample nameColon cancer
Molecules identified in the studydsDNA
Methods used in the studyddPCR
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3
Experiment ID3544
Identified moleculedsDNA
Identification methodddPCR
PubMed ID 31232418   
OrganismHomo sapiens
Experiment descriptionEnrichment of extracellular vesicles with lipid nanoprobe functionalized nanostructured silica
AuthorsWan Y, Maurer M, He HZ, Xia YQ, Hao SJ, Zhang WL, Yee NS, Zheng SY.
Journal name Lab Chip
Publication year2019
SamplePlasma
Sample namePancreatic cancer
Molecules identified in the studydsDNA
Methods used in the studyddPCR
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4
Experiment ID3541
Identified moleculedsDNA
Identification methodWhole exosome sequencing
PubMed ID 31596073   
OrganismHomo sapiens
Experiment descriptionIsolation and Retrieval of Extracellular Vesicles for Liquid Biopsy of Malignant Ground-Glass Opacity
AuthorsMao W, Wen Y, Lei H, Lu R, Wang S, Wang Y, Chen R, Gu Y, Zhu L, Abhange KK, Quinn ZJ, Chen Y, Xue F, Zheng M, Wan Y.
Journal name Anal Chem
Publication year2019
SamplePlasma
Sample nameLung adenocarcinoma
Molecules identified in the studydsDNA
Methods used in the studyWhole exosome sequencing
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5
Experiment ID3539
Identified moleculedsDNA
Identification methodWhole exosome sequencing
PubMed ID 33915956   
OrganismHomo sapiens
Experiment descriptionExosomes from Plasma of Neuroblastoma Patients Contain Doublestranded DNA Reflecting the Mutational Status of Parental Tumor Cells
AuthorsDegli Esposti C, Iadarola B, Maestri S, Beltrami C, Lavezzari D, Morini M, De Marco P, Erminio G, Garaventa A, Zara F, Delledonne M, Ognibene M, Pezzolo A.
Journal name Int J Mol Sci
Publication year2021
SamplePlasma
Sample nameNeuroblastoma
Molecules identified in the studydsDNA
Methods used in the studyWhole exosome sequencing
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6
Experiment ID3552
Identified moleculedsDNA
Identification methodNext generation sequencing
PubMed ID 31555514   
OrganismHomo sapiens
Experiment descriptionLiquid biopsies using pleural effusion-derived exosomal DNA in advanced lung adenocarcinoma
AuthorsSong Z, Cai Z, Yan J, Shao YW, Zhang Y.
Journal name Transl Lung Cancer Res
Publication year2019
SamplePleural effusion
Sample nameLung adenocarcinoma
Molecules identified in the studydsDNA
Methods used in the studyNext generation sequencing
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7
Experiment ID3555
Identified moleculedsDNA
Identification methodPCR
Sanger sequencing
Whole genome shotgun sequencing
PubMed ID 24398677   
OrganismHomo sapiens
Experiment descriptionIdentification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer
AuthorsKahlert C, Melo SA, Protopopov A, Tang J, Seth S, Koch M, Zhang J, Weitz J, Chin L, Futreal A, Kalluri R.
Journal name J Biol Chem
Publication year2014
SampleSerum
Sample namePancreatic cancer
Molecules identified in the studydsDNA
Methods used in the studyPCR
Sanger sequencing
Whole genome shotgun sequencing
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